후두, 갑상선, 위에 발생한 다발암 1례

Since Billroth (1869) first recognized that a single patient can develop simultaneous independant cancers, numerous series documenting multiple primary cancers have appeared in the literatures. Today, it is well documented that multiple primary cancers are also not unusual in patients with head and neck cancers, and can arise in related or different organs. Reported incidences of multiple primary cancers in head and neck cancers in various studies are in the range of 10∼35%. The histologic criteria for the diagnosis of multicentric neoplasms as originally described by Waren and Gates remains valid: 1) The neoplasms must be clearly malignant on histologic examination, 2) Each neoplasm must be geographically separate and distinct and not connected by either submucosal or intraepithelial neoplastic change, 3) The possibility that the second neoplasm represents a metastasis must be excluded.

Recently, we experienced a case of multiple primary cancers occured in the larynx (squamous cell carcinoma ), thyroid gland(papillary carcinoma), and stomach (adenocarcinoma) and report this case with brief review of literatures.