Localization of Substance P-like Immunoreactive Innervation in the Nasal Mucosa of the Guinea Pig.

Jeon, Sea Yuong; Jeong, Pil Seob; Hwang, Eui Gee; Hong, Soon Kwan; Majima, Yuichi; Sakakura, Yasuo

doi:10.35420/jcohns.1992.3.2.280

J Clin Otolaryngol Head Neck Surg 1992; 3(2):280-287

pISSN: 1225-0244, eISSN: 2713-833X

DOI: https://doi.org/10.35420/jcohns.1992.3.2.280

Article

기니픽 비점막의 Substance P 신경섬유 분포에 대한 면역조직화학적 연구

전시영¹, 정필섭¹, 황의기¹, 홍순관¹, 間島雄ᅳ², 坂倉康夫²

Localization of Substance P-like Immunoreactive Innervation in the Nasal Mucosa of the Guinea Pig.

Sea Yuong Jeon¹, Pil Seob Jeong¹, Eui Gee Hwang¹, Soon Kwan Hong¹, Yuichi Majima², Yasuo Sakakura²

Author Information & Copyright ▼

¹경상대학교 의과대학 이비인후과학교실

²日本國三重*學醫學部耳鼻科

¹Department of Otolaryngology, College of Medicine, Kyeong Sang National University

²Department of Otolaryngology, College of Medicine, Mie University, Japan

© Copyright 1992 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: May 31, 2020

ABSTRACT

Substance P-like immunoreactive(SP-IR) innervation in the nasal mucosa of the guinea pig was localized by the avidin-biotin-peroxidase(ABC) method of immunohistochemistry. SP-IR innervation was distributed within lining epithelium, in subepithelial layer, along the wall of vessels and around glands, but also within nasal glandular structures.

These findings suggest the morphologic evidence of local neuronal reflex networks between norciception on surface epithelium and actions in local vascular bed and on submucosal glands.

Keywords: substance P; immunohistochemistry; ABC method; nasal mucosa; nasal gland