Journal of Clinical Otolaryngology Head and Neck Surgery
The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery
Article
기니픽 비점막의 Substance P 신경섬유 분포에 대한 면역조직화학적 연구
전시영1, 정필섭1, 황의기1, 홍순관1, 間島 雄ᅳ2, 坂倉康夫2
Sea Yuong Jeon1, Pil Seob Jeong1, Eui Gee Hwang1, Soon Kwan Hong1, Yuichi Majima2, Yasuo Sakakura2
Published Online: May 31, 2020
ABSTRACT
Substance P-like immunoreactive(SP-IR) innervation in the nasal mucosa of the guinea pig was localized by the avidin-biotin-peroxidase(ABC) method of immunohistochemistry. SP-IR innervation was distributed within lining epithelium, in subepithelial layer, along the wall of vessels and around glands, but also within nasal glandular structures.
These findings suggest the morphologic evidence of local neuronal reflex networks between norciception on surface epithelium and actions in local vascular bed and on submucosal glands.
Keywords: substance P; immunohistochemistry; ABC method; nasal mucosa; nasal gland