원저

후두이형성증이 침윤성 암종으로의 전환에 영향을 미치는 병리조직학적 지표

김찬우1, 구지영1, 오승철1, 장일환1, 차흥억1, 조현이2
Chan Woo Kim1, Ji Young Gu1, Seung Chul Oh1, II Hwan Jang1, Heung Eog Cha1, Hyuni Cho2
Author Information & Copyright
1가천의과대학부속 길병원 이비인후-두경부외과학교실
2해부병리과학교실
1Department of Otolaryngology-Head and Neck Surgery, Pathology,Gachon Medical College, Inchon, Korea
2Gil Hospital,Gachon Medical College, Inchon, Korea

© Copyright 1998 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: May 31, 2020

ABSTRACT

Background: Laryngeal dysplasia was well known for premalignant lesion of larynx. Despite this well recognized association, histologic changes that predict the presence of irreversible neoplastic transformation remain poorly defined for laryngeal cancer.

Objectives: We performed this study for the purpose of determining histopathologic parameters affecting malignant transformation of laryngeal dysplasia.

Material and Methods: A chart review was made of 16 patients with laryngeal dysplasia (mean follow up, 28 months). Various histopatholgic parameters were assessed to define the progression from dysplasia to invasive carcinoma.

Results: Mitotic activity, maturation level, nuclear pleomorphism, nucleolar prominence and dyskeratosis were significant in progression of dysplasia to invasive carcinoma.

Conclusions: In our study, five specific histopathologic parameters were found to be significant in the progression of laryngeal dysplasia to invasive carcinoma. But surface keratinization, stromal inflammation, acanthosis, koilocytosis and abnormal mitotic figures had no apparent impact on outcome.

Keywords: Laryngeal dysplasia; Histopathologic parameters; Invasive carcinoma


임상이비인후과 학술상 공지


안녕하십니까.

대한이비인후과학회 부산울산경남지부회에서는

회원분들의 학술 연구를 장려하는 의미에서 

2022년도부터 학술상을 신설해 수여하고자 합니다. 

 

임상이비인후과 학술상

1. 2022년에 본 학술지에 게재된 논문중

인용횟수 및 학술적 가치가 높은 연구주제에 대해

편집위원회에서 선정 후 수여

2. 수상자는 논문의 교신저자로 함

3. 시상 - 상장 및 상금 50만원

4. 시상일 - 추후 공지

5. 편집위원회에서 선정하므로 별도의 신청 필요 없음

 

- 관련문의 

 임상이비인후과 편집위원회  jco.hns.1990@gmail.com


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