후두이형성증이 침윤성 암종으로의 전환에 영향을 미치는 병리조직학적 지표

Background: Laryngeal dysplasia was well known for premalignant lesion of larynx. Despite this well recognized association, histologic changes that predict the presence of irreversible neoplastic transformation remain poorly defined for laryngeal cancer.

Objectives: We performed this study for the purpose of determining histopathologic parameters affecting malignant transformation of laryngeal dysplasia.

Material and Methods: A chart review was made of 16 patients with laryngeal dysplasia (mean follow up, 28 months). Various histopatholgic parameters were assessed to define the progression from dysplasia to invasive carcinoma.

Results: Mitotic activity, maturation level, nuclear pleomorphism, nucleolar prominence and dyskeratosis were significant in progression of dysplasia to invasive carcinoma.

Conclusions: In our study, five specific histopathologic parameters were found to be significant in the progression of laryngeal dysplasia to invasive carcinoma. But surface keratinization, stromal inflammation, acanthosis, koilocytosis and abnormal mitotic figures had no apparent impact on outcome.