Journal of Clinical Otolaryngology Head and Neck Surgery

The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery

J Clin Otolaryngol Head Neck Surg 1998; 9(1):96-101

pISSN: 1225-0244, eISSN: 2713-833X

DOI: https://doi.org/10.35420/jcohns.1998.9.1.96

원저

후두이형성증이 침윤성 암종으로의 전환에 영향을 미치는 병리조직학적 지표

김찬우¹, 구지영¹, 오승철¹, 장일환¹, 차흥억¹, 조현이²

Histopathologic Parameters Affecting Transformation to Invasive Carcinoma of Laryngeal Dysplasia

Chan Woo Kim¹, Ji Young Gu¹, Seung Chul Oh¹, II Hwan Jang¹, Heung Eog Cha¹, Hyuni Cho²

¹가천의과대학부속 길병원 이비인후-두경부외과학교실

²해부병리과학교실

¹Department of Otolaryngology-Head and Neck Surgery, Pathology，Gachon Medical College, Inchon, Korea

²Gil Hospital，Gachon Medical College, Inchon, Korea

© Copyright 1998 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: May 31, 2020

ABSTRACT

Background: Laryngeal dysplasia was well known for premalignant lesion of larynx. Despite this well recognized association, histologic changes that predict the presence of irreversible neoplastic transformation remain poorly defined for laryngeal cancer.

Objectives: We performed this study for the purpose of determining histopathologic parameters affecting malignant transformation of laryngeal dysplasia.

Material and Methods: A chart review was made of 16 patients with laryngeal dysplasia (mean follow up, 28 months). Various histopatholgic parameters were assessed to define the progression from dysplasia to invasive carcinoma.

Results: Mitotic activity, maturation level, nuclear pleomorphism, nucleolar prominence and dyskeratosis were significant in progression of dysplasia to invasive carcinoma.

Conclusions: In our study, five specific histopathologic parameters were found to be significant in the progression of laryngeal dysplasia to invasive carcinoma. But surface keratinization, stromal inflammation, acanthosis, koilocytosis and abnormal mitotic figures had no apparent impact on outcome.

Keywords: Laryngeal dysplasia; Histopathologic parameters; Invasive carcinoma