원저

기니픽 상기도의 Vasoactive Intestinal Polypeptide 함유 신경의 분포

전시영1, 성재준1, 송병욱1, 박정제1, 정태기1, 심보성1
Sea Young Jeon1, Jae Jun Sung1, Byung Uk Song1, Jung Je Park1, Tae Gee Jung1, Bo Seong Sim1
Author Information & Copyright
1경상대학교 의과대학 이비인후과학교실
1Department of Otolaryngology, College of Mediene, Kyung Sang Unwersiiy,Jin Ju, Korea

© Copyright 1997 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: May 31, 2020

ABSTRACT

Vasoactive intestinal polypeptide(VIP) is a 28-amino acid peptide extracted from porcine duodenum as a potent vasodilator, originally. Current evidence suggests that VIP mediates inhibitory-nonadrenergic noncholinergic effects in the respiratory tract of several species, including human. It has been reported that vasoactive intestinal polypeptide-containing nerves relax the airway smooth muscle and blood vessels and stimulate glandular secretion in the airway mucosa.

The present study was undertaken to localize VlP-containing nerves in the upper airway oi the guinea pig using rabbit anti-VIP serum and avidin- biotin-complex method.

VIP-containing nerves were distributed around glands, excretory duct, along sinusoid wall and around small blood vessels of nasal mucosa and distributed in the smooth muscle of trachea. Some VIP-containing ganglion cells were distributed in the sphenopalatine ganglion.

In conclusion, these finding imply that VIP coexists with acetylcholine along the cholinergic nerve fibers in the airway mucosa and has regulatory function in glandular secretion, vasodilation and bronchodilation in the upper airway of the guinea pig.

Keywords: Vasoactive intestinal polypeptide; Immunohistochemistry nasal mucosa; Sphenopalatine ganglion; Tracheal smooth muscle