악하선의 악성혼합종양

Malignant mixed tumor of the salivary gland is defined as the carcinoma arising from the previous benign mixed tumor, and it is mainly developed in the parotid gland, but less likely the submandibular gland. Malignant mixed tumor include three different clinical and pathologic entities: carcinoma ex mixed tumor, carcinosarcoma, metastasizing mixed tumor.

Because of various histopathological pattern and oncogenic modality of the malignant mixed tumor in the submandibular gland, it is more difficult to make a early diagnosis and treatment in the submandibular gland than those in the parotid gland.

Recently, we had experienced two cases of the carcinoma ex mixed tumor arising from the benign mixed tumors in the submandibular glands. In both cases, constant sized, painless ruberry submandibular gland masses for a long time showed the evidences of malignant transformation as the abrupt increase of the mass size, adhesion to the adjuvant structures. Radical submandibular gland resection and selective neck dissection were performed with adjuvant radiation therapy in both cases. All the patients have been well on. So, we report on this cases with a brief review of literatures.