인두 신경증과 위식도 역류의 상관관계에 대한 예비연구

The term globus syndrome is used to describe those patients complaining of a discomfort or lump sensation in the throat without any determined causal factor. In order to study the relationship between globus syndrome and G-E reflux, 43 patients with globus symptom were evaluated. In our study, globus syndrome was two times more common in women, and most frequently in the fourth decade. Thirty three(77%) out of forty three patients had suffered gastrointestinal discomfort and 22 cases underwent UGI or endoscopic study previously. In a prospective trial, barium esophagogram and gastric scintigram were performed in 21 and 8 cases respectively in order to confirm the association between acid refulx and globus syndrome. Only two pathologic findings were diagnosed in barium study, whereas among the 8 cases who were examined with gastric scintigram 5 definite G-E reflux were noted. Antireflux medication was begun in all of the globus patients. 38 Cases(90%) were either significantly improved or rendered completely symptom-free after antireflux therapy. There was no difference in treatment effect in patients with globus only and patients with globus plus G-I discomfort.