아황산가스가 백서 기관상피에 미치는 영향에 관한 광학현미경 및 주사전자현미경적 연구

Sulfur dioxide, one of the important environmental pollutants, has been related to the increased morbidity rates or death due to respiratory damage. To investigate the effects of sulfur dioxide on the tracheal epithelium, and experiment was performed with 48 mice from the same colony. Experimental animals were divided into 3 groups, 30-minute exposure group, 60-minute exposure group, and 120-minute exposure group to 20 ppm sulfur dioxide gas.

Histopathological findings of mice exposed to sulfur dioxide were studied in each groups with light microscope immediately, 24 hours and 48 hours after sulfur dioxide exposure. No specific differences were noted among 3 group.

Scanning electron microscopic examination showed a tendency for ciliary compounding and ciliary lying-down in tracheal epithelium of mice exposed to sulfur dioxide. Ciliary compounding and lying-down were increased in severity as the exposure time was increased. However, ciliary compounding and lying-down disappeared 48 hours after exposure in all groups.