Journal of Clinical Otolaryngology Head and Neck Surgery
The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery
원저

아황산가스가 백서 기관상피에 미치는 영향에 관한 광학현미경 및 주사전자현미경적 연구

홍석찬1, 추무진2
Seok-Chan Hong1, Moo-Jin Choo2
1건국대학교 의과대학 이비인후과학교실
2충북대학교 의과대학 이비인후과학교실
1Department of Otolaryngology, College of Medicine, Kon-Kuk University
2Department of Otolaryngology, College of Medicine, Chung-Buk University

© Copyright 1994 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: May 31, 2020

ABSTRACT

Sulfur dioxide, one of the important environmental pollutants, has been related to the increased morbidity rates or death due to respiratory damage. To investigate the effects of sulfur dioxide on the tracheal epithelium, and experiment was performed with 48 mice from the same colony. Experimental animals were divided into 3 groups, 30-minute exposure group, 60-minute exposure group, and 120-minute exposure group to 20 ppm sulfur dioxide gas.

Histopathological findings of mice exposed to sulfur dioxide were studied in each groups with light microscope immediately, 24 hours and 48 hours after sulfur dioxide exposure. No specific differences were noted among 3 group.

Scanning electron microscopic examination showed a tendency for ciliary compounding and ciliary lying-down in tracheal epithelium of mice exposed to sulfur dioxide. Ciliary compounding and lying-down were increased in severity as the exposure time was increased. However, ciliary compounding and lying-down disappeared 48 hours after exposure in all groups.

Keywords: Sulfur dioxide; Scanning electron microscope; Light microscope; Ciliary compounding and lying-down