PDF Download
PubReader
Export Citation
Share Facebook
Share Twitter
Cited by 0 Article
Metrics (View:2,796)
Hyaluronan을 이용한 고막천공의 치료
Published Online: May 31, 2020
Abstract
Glycosaminoglycan(1%, Hyaluronan) is a linear polysaccharide formed disaccharide units containing N-acetyl glucosamine and glucuronic acid, the mechanism of action of which on the healing pattern is not well known, but it contains water and also has a water attractive property by a colloid osmotic mechanism, and may thus serve as a water lubricant and a scaffold support for a marked hyperplasia of the outer squamous epitheium of the drum with an excessive keratin production.
15 unselected patients with tympanic membrane perforation of varying size, location and various duration from 10 days to over 10 years were treated by local application of the Hyaluronan, at the ENT department of Inchon Christian Hospital from July 1992 to March 1993.
The following treatment results were obstained:
No side effects of hyaluronan were seen during the course of treatment.
8 cases(53%) were closed but 7 cases(47%) were not. The large perforations(4 cases) were not healed, although slightly reduced in size, but small and medium sized perforations(8 cases) were healed, although medium sized perforations(2 cases) were excluded with pulsation due to infection and small sized perforation (1 case) was also excluded with reperforation after healing.
We might conclude that hyaluronic acid has a good effect in the healing of the perforated TM including traumatic ear drum preforation，perforation after AOM and COM, persistent perforation after extraction of ventilation tube and re-perforation after tympanoplasty.