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Journal of Clinical Otolaryngology Head and Neck Surgery
The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery

J Clin Otolaryngol Head Neck Surg 1993; 4(2):293-298

pISSN: 1225-0244, eISSN: 2713-833X

DOI: https://doi.org/10.35420/jcohns.1993.4.2.293

원저

Hyaluronan을 이용한 고막천공의 치료

신성이1, 윤희영1, 조규종1, 홍승모1, 이상훈1, 김훈1
Treatment of Tympanic Membrane Perforation with Hyaluronan
Sung Lee Shin1, Hee Young Yoon1, Gyu Jong Cho1, Seung Mo Hong1, Sang Hoon Lee1, Hoon Kim1
1인천기독병원 이비인후과
1Department of Otolaryngology, Inchon Christian Hospital

© Copyright 1993 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: May 31, 2020

Abstract

Glycosaminoglycan(1%, Hyaluronan) is a linear polysaccharide formed disaccharide units containing N-acetyl glucosamine and glucuronic acid, the mechanism of action of which on the healing pattern is not well known, but it contains water and also has a water attractive property by a colloid osmotic mechanism, and may thus serve as a water lubricant and a scaffold support for a marked hyperplasia of the outer squamous epitheium of the drum with an excessive keratin production.

15 unselected patients with tympanic membrane perforation of varying size, location and various duration from 10 days to over 10 years were treated by local application of the Hyaluronan, at the ENT department of Inchon Christian Hospital from July 1992 to March 1993.

The following treatment results were obstained:

  1. No side effects of hyaluronan were seen during the course of treatment.

  2. 8 cases(53%) were closed but 7 cases(47%) were not. The large perforations(4 cases) were not healed, although slightly reduced in size, but small and medium sized perforations(8 cases) were healed, although medium sized perforations(2 cases) were excluded with pulsation due to infection and small sized perforation (1 case) was also excluded with reperforation after healing.

    We might conclude that hyaluronic acid has a good effect in the healing of the perforated TM including traumatic ear drum preforation，perforation after AOM and COM, persistent perforation after extraction of ventilation tube and re-perforation after tympanoplasty.

Keywords: Tympanic Membrane Perforation; Hyaluronic Acid