두경부 악성종양에 대한 Cisplatin과 Peplomycin의 병용요법

Between Jan. 1, 1989 and May 31, 1991, 66 patients with head and neck carcinoma were treated with cisplatin and peplomycin. Cis-diamminodichloroplatinum(DDP) 80∼100 mg/m² iv was given after prehydration, with mannitol diuresis on day 1, followed by peplomycin l0mg/18 hr iv from days 3 to 10 and second cycle chemotherapy was repeated on day 22.

Of 66 patients, 13 had a complete response and 26 had a partial response with an overall response rate of 59%.Patients who had a complete response had been given over 2 courses of the therapy. Concerning response by histology, the response rate was 60 ^ in cases of squamous cell carcinoma. In this trial, nasopharyngeal and paranasal sinus carcinoma well responded to the therapy. Chemotherapy toxicity in 66 patients included nausea, vomiting(66), alopecia(66), fever(10), skin rash(3), renal toxicity(6), WBC less than 3,000(2) and anemia (11).

Cisplatin and Peplomycin therapy is therefore concluded to be effective for squamous cell carcinomas of head and neck.