Journal of Clinical Otolaryngology Head and Neck Surgery

The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery

J Clin Otolaryngol Head Neck Surg 1992; 3(1):106-114

pISSN: 1225-0244, eISSN: 2713-833X

DOI: https://doi.org/10.35420/jcohns.1992.3.1.106

원저

두경부 악성종양에 대한 Cisplatin과 Peplomycin의 병용요법

김선태¹, 조재식¹, 이종원¹, 정찬중¹

Combination Chemotherapy with Cisplatin and Peplomycin in Head and Neck Cancer

Seon Tae Kim¹, Jae Sik Cho¹, Chong Won Lee¹, Chan Joong Jeong¹

¹전남대학교 의과대학 이비인후과학교실

¹Department of Otolaryngology, College of Medicine, Chonnam National University

© Copyright 1992 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: May 31, 2020

ABSTRACT

Between Jan. 1, 1989 and May 31, 1991, 66 patients with head and neck carcinoma were treated with cisplatin and peplomycin. Cis-diamminodichloroplatinum(DDP) 80∼100 mg/m² iv was given after prehydration, with mannitol diuresis on day 1, followed by peplomycin l0mg/18 hr iv from days 3 to 10 and second cycle chemotherapy was repeated on day 22.

Of 66 patients, 13 had a complete response and 26 had a partial response with an overall response rate of 59%.Patients who had a complete response had been given over 2 courses of the therapy. Concerning response by histology, the response rate was 60 ^ in cases of squamous cell carcinoma. In this trial, nasopharyngeal and paranasal sinus carcinoma well responded to the therapy. Chemotherapy toxicity in 66 patients included nausea, vomiting(66), alopecia(66), fever(10), skin rash(3), renal toxicity(6), WBC less than 3,000(2) and anemia (11).

Cisplatin and Peplomycin therapy is therefore concluded to be effective for squamous cell carcinomas of head and neck.

Keywords: Combination chemotherapy; Cisplatin; Peplomycin