성대 반흔에 대한 조직공학적 치료

Laryngologists frequently are confronted with patients who have remained or become dysphonia after laryngeal surgery or trauma. One of major these reason is vocal fold scar. Although behavioral, pharmacological, and surgical intervention have been offered in an attempt to improve or regenerate scarred vocal fold mucosa, the ideal treatment for vocal fold scar has not yet been found. Several tissue engineering technique for vocal fold scar have recently been described in tissue culture and animal model. Cell types for tissue engineering of vocal fold scar have been native or scarred vocal fold fibroblast, autologous fibroblast from nonlaryngeal tissue, adult mesenchymal stem cells. Decellularized organ matrix, biologic polymers, synthetic biomimetic hydrogels, and synthetic polymers have used as scaffold. The chemical and mechanical stimulation, such as hepatic growth factor and vibration stress, have been described for the effect of the maturation of implanted cells. Multiple tissue engineering approaches hold promise for reproducing functional vocal fold tissue. (J Clinical Otolaryngol 2010;21:191–198)