Journal of Clinical Otolaryngology Head and Neck Surgery
The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery

성대 반흔에 대한 조직공학적 치료

Byung-Joo Lee1,*
1부산대학교 의학전문대학원 이비인후과학교실
1Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine, Busan, Korea
*교신저자: 이병주, 602-739 부산광역시 서구 아미동 1가 10 부산대학교 의학전문대학원 이비인후과학교실 전화 :(051) 240-7335·전송:(051) 246-8668 E-mail:

© Copyright 2010 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: May 31, 2020


Laryngologists frequently are confronted with patients who have remained or become dysphonia after laryngeal surgery or trauma. One of major these reason is vocal fold scar. Although behavioral, pharmacological, and surgical intervention have been offered in an attempt to improve or regenerate scarred vocal fold mucosa, the ideal treatment for vocal fold scar has not yet been found. Several tissue engineering technique for vocal fold scar have recently been described in tissue culture and animal model. Cell types for tissue engineering of vocal fold scar have been native or scarred vocal fold fibroblast, autologous fibroblast from nonlaryngeal tissue, adult mesenchymal stem cells. Decellularized organ matrix, biologic polymers, synthetic biomimetic hydrogels, and synthetic polymers have used as scaffold. The chemical and mechanical stimulation, such as hepatic growth factor and vibration stress, have been described for the effect of the maturation of implanted cells. Multiple tissue engineering approaches hold promise for reproducing functional vocal fold tissue. (J Clinical Otolaryngol 2010;21:191–198)

Keywords: 성대 반흔; 조직 공학; 섬유아세포; 중간엽 줄기세포; 히알루론산
Keywords: Vocal fold scar; Tissue engineering; Fibroblast; Mesenchymal stem cells; Hyaluronic acid