원저

중이진주종에서 Telomerase의 발현

김현철1, 고의경1,*, 이병주1, 이일우1, 전경명1
Hyun-Chul Kim1, Eui-Kyung Goh1,*, Byung-Joo Lee1, Il-Woo Lee1, Kyong-Myong Chon1
Author Information & Copyright
1부산대학교 의과대학 이비인후과학교실
1Department of Otolaryngology, College of Medicine, Pusan National University, Busan, Korea
*교신저자: 고의경, 602-739 부산광역시 서구 아미동 1가 10번지 부산대학교 의과대학 이비인후과학교실 전화: (051) 240-7332·전송: (051) 246-8668 E-mail: gohek@pusan.ac.kr

© Copyright 2005 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Apr 17, 2005; Accepted: May 10, 2005

Published Online: May 31, 2020

ABSTRACT

Background and Objectives: Telomerase maintains the length of telomeres in immortal cell and also is often associated with cell proliferation. Cholesteatoma epithelium is characterized by a dysregulation with a hyperproliferative growth. We studied to evaluate of the telomerase activity in cholesteatoma and normal retroau- ricular skin and to know the relationship between telomerase expression and clinical findings. Materials and Methods: Twenty-two cholesteatomas and fifteen retroauricular skins were obtained from patients undergoing middle ear surgery. The detection of telomerase activity was done by TRAP assay methods. To know the relationship between telomerase expression and clinical findings, author analyzed clinical findings including hearing level, duration of disease, and degree of extension retrospectively. Results: Seventeen of 22 cholesteatoma (77.3%) expressed telomerase activity, whereas none of 15 retroauricular normal skin (0%) detected telomerase activity. There was no any significant differences between clinical findings including hearing level, duration of disease, and degree of extension, and telomerase activity (p>0.05). Conclusion: The highly expression of telomerase in cholesteatoma suggests that the telomerase activation may be related with the proliferative nature in cholesteatoma. (J Clinical Otolaryngol 2005;16:66–72)

Keywords: 델로멀레이즈; 진주종성중이염; 증식능
Keywords: Telomerase; Cholesteatoma; Proliferation