신이식 후 연구개와 구개 편도에 발생한 Epstein-Barr Virus 양성인 말초성 T 세포 림프종 1예

Posttransplant lymphoproliferative disorder (PTLD) is a heterogenous group of lymphoid proliferative disorders ranging from non-specific reactive hyperplasia to malignant lymphoma occurring in transplant patients. The origins of PTLD are mostly B lymphocytes and linked to Epstein-Barr virus (EBV) infection, but T lymphocyte PTLDs are uncommon and not associated with EBV infection. We report a case of EBV-associated peripheral T-cell lymphoma involving soft palate and left palatine tonsil occurring in a 35 year old female patient 14 years after renal allograft transplantation. Positivity for CD3 demonstrated in the tumor cells, while CD56 was not expressed. We detected positive reaction for EBV-encoded RNAs (EBERs) in the neoplastic cells by in situ hybridization. She is being treated by chemotherapy at present after surgical removal of lesion and reduction of immunosuppression. (J Clinical Otolaryngol 2004;15:286-289)