Journal of Clinical Otolaryngology Head and Neck Surgery

The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery

J Clin Otolaryngol Head Neck Surg 2004; 15(2):286-289

pISSN: 1225-0244, eISSN: 2713-833X

DOI: https://doi.org/10.35420/jcohns.2004.15.2.286

증례

신이식 후 연구개와 구개 편도에 발생한 Epstein-Barr Virus 양성인 말초성 T 세포 림프종 1예

김상렬¹^,^*, 엄재욱¹, 최정배¹, 김찬환²

A Case of Epstein-Barr Virus-associated Peripheral T-cell Lymphoma Involving Soft Palate and Left Palatine Tonsil in Renal Transplant Recipient

Sang Ryul Kim¹^,^*, Jae Wook Eom¹, Jung Bae Choi¹, Chan Hwan Kim²

¹인제대학교 의과대학 부산백병원 이비인후-두경부외과학교실

²병리학교실

¹Department of Otolaryngology-Head & Neck Surgery, Inje University, Pusan Paik Hospital, Busan, Korea

²Pathology, College of Medicine, Inje University, Pusan Paik Hospital, Busan, Korea

^*교신저자: 김상렬, 614-735 부산광역시 부산진구 개금동 633-165 인제대학교 의과대학 부산백병원 이비인후-두 경부외과학교실 전화: (051) 890-6176·전송: (051) 892-3831 E-mail: iment1@yahoo.co.kr

© Copyright 2004 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Oct 03, 2004; Accepted: Nov 23, 2004

Published Online: May 31, 2020

ABSTRACT

Posttransplant lymphoproliferative disorder (PTLD) is a heterogenous group of lymphoid proliferative disorders ranging from non-specific reactive hyperplasia to malignant lymphoma occurring in transplant patients. The origins of PTLD are mostly B lymphocytes and linked to Epstein-Barr virus (EBV) infection, but T lymphocyte PTLDs are uncommon and not associated with EBV infection. We report a case of EBV-associated peripheral T-cell lymphoma involving soft palate and left palatine tonsil occurring in a 35 year old female patient 14 years after renal allograft transplantation. Positivity for CD3 demonstrated in the tumor cells, while CD56 was not expressed. We detected positive reaction for EBV-encoded RNAs (EBERs) in the neoplastic cells by in situ hybridization. She is being treated by chemotherapy at present after surgical removal of lesion and reduction of immunosuppression. (J Clinical Otolaryngol 2004;15:286-289)

Keywords: 이식후 림프세포증식성 질환; 말초성 T 세포림프종; Epstein-Barr virus; 신이식; 연구개

Keywords: Posttransplant lymphoproliferative disorder (PTLD); Peripheral T-cell lymphoma; Epstein-Barr virus; Renal transplantation; Soft palate