알레르기 피부 단자 검사를 통한 흡입 항원과 음식 항원의 교차반응에 관한 분석

Background and Objectives: A cross-reaction between foods and other allergens can be dangerous for asthmatics and, in severe cases, can result in the onset of anaphylatic shock and can aggravate symptoms for patients with atopic dermatitis and allergic rhinitis. This study aimed to find out the cross-reactivity between inhalant and food allergens through retrospective review of large number of cases showing positive allergen skin prick test. Materials and Method: Total 3,522 cases showing positive allergen skin prick test from Jan 1991 to Jan 2001 at Allergy Clinic in St. Benedict Hospital, Pusan, Korea were analyzed retrospectively. The allergen skin prick test consisted of 55 allergen, dividing into groups of house dust and mite, epithelials, pollens, molds, and foods. Results: The common offending allergen groups were dust and mites (56.0%), pollens (43.3%), and epithelials (39.3%) group. The most common offending single allergen was D. fariane (48.7%), followed by D. pteronyssinus, straw dust, cat fur, dog hair, alder and birch pollen, cockroach. The most common offending allergen among pollen group was alder pollen (26.2%), followed by birch, hazel, beech, mugwort. The common cross-reactive groups in patients with positive food allergen was dust and mites (51.1%), followed by pollens (35.7%), epithelials (20%), molds (10%) group. Common food allergens in patients with positive dust and mites allergen were shrimp and crab. And the common food allergens in patients with positive pollen group were bean and wheat for alder and hazel pollen, and were apple and peach for birch pollen. Conclusion: These result suggest a cluster of cross-reaction between dust and mites and crustacea like shrimp and crab, and between birch and apple, peach. (J Clinical Otolaryngol 2003;14:275-281)