알레르기성 비염의 비점막에서 γδ T림프구의 분포에 관한 면역조직화학적 연구

Background and Objectives: T cells expressing γδ receptors are present in various organs and are known to play an important role in local immunity against foreign antigens. They are supposed to be activated by the superantigen or heat shock protein. However, characteristics of γδ T cells in nasal mucosa was not known. We observed the distribution of CD3+ T cells and γδ T cells in nasal mucosa to investigate the role of γδ T cells in allergic rhinitis. Materials & Methods: Mucosal specimens were obtained from inferior turbinate of patients with allergic rhinitis, chronic hypertrophic rhinitis, and normal inferior turbinate. Frozen specimens were stained using immunohistochemistry and immunopositive cells were counted. Results: CD3+ T cell distribution was not different between the groups. In epithelial layer, number of γδ T cells were higher in allergic rhinitis (2.1 ±0.7/high power field) than chronic hypertrophic rhinitis (0.5 ±0.1/high power field) and normal inferior turbinate (0.3±0.2/high power field), but in lamina propria their counts were not different between the groups. Conclusions: Increased proportion of γδ T cells in allergic rhinitis suggests that γδ T cells may play an some role in pathogenesis of allergic rhinitis in epithelial layer of allergic rhinitis. (J Clinical Otolaryngol 2000;11:87–91)