원저

알레르기성 비염의 비점막에서 γδ T림프구의 분포에 관한 면역조직화학적 연구

김선태1,*, 오승철1, 김찬우1, 장일환1, 차흥억1, 이흥만2
Seon Tae Kim1,*, Seung Chul Oh1, Chan Woo Kim1, Il Hwan Jang1, Heung Eog Cha1, Heung-Man Lee2
Author Information & Copyright
1가천의과대학 부속길병원 이비인후과학교실
2고려대학교 의과대학 이비인후과학교실
1Department of Otolaryngology-Head & Neck Surgery, Gil Hospital, Gachon Medical School, Inchon, Korea
2Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Korea University, Seoul, Korea
*교신저자: 김선태, 405-760 인천광역시 남동구 구월동 1198 가천의과대학 부속길병원 이비인후과학교실 전화: (032) 460-3762· 전송: (032) 467-9044 E-mail: Rhinokim@ghil.com

© Copyright 2000 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Mar 30, 2000; Accepted: May 22, 2000

Published Online: May 31, 2020

ABSTRACT

Background and Objectives: T cells expressing γδ receptors are present in various organs and are known to play an important role in local immunity against foreign antigens. They are supposed to be activated by the superantigen or heat shock protein. However, characteristics of γδ T cells in nasal mucosa was not known. We observed the distribution of CD3+ T cells and γδ T cells in nasal mucosa to investigate the role of γδ T cells in allergic rhinitis. Materials & Methods: Mucosal specimens were obtained from inferior turbinate of patients with allergic rhinitis, chronic hypertrophic rhinitis, and normal inferior turbinate. Frozen specimens were stained using immunohistochemistry and immunopositive cells were counted. Results: CD3+ T cell distribution was not different between the groups. In epithelial layer, number of γδ T cells were higher in allergic rhinitis (2.1 ±0.7/high power field) than chronic hypertrophic rhinitis (0.5 ±0.1/high power field) and normal inferior turbinate (0.3±0.2/high power field), but in lamina propria their counts were not different between the groups. Conclusions: Increased proportion of γδ T cells in allergic rhinitis suggests that γδ T cells may play an some role in pathogenesis of allergic rhinitis in epithelial layer of allergic rhinitis. (J Clinical Otolaryngol 2000;11:87–91)

Keywords: 알레르기성 비염; γδ T 림프구
Keywords: γδ T cells; CD3+ Tcells; Allergic rhinitis