비용 발생에서 알레르기의 역할과 T 세포의 분포

Background and Objective: The exact pathogenesis of nasal polyp is unknown, but inflammation is thought to be an important factor in the developement of nasal polyposis. Histologically, the stroma of nasal polyps consists of variable inflammatory cellular infiltrates. Eosinophil and lymphocyte are an important inflammatory cells. The purpose of this study is to understand the role of allergy and distribution of T cell in pathogenesis of nasal polyps. Materials and Method: We performed the analysis of allergic test and inflammatory cells in the nasal polyps, allergic inferior turbinate mucosas and hypertrophic inferior turbinate mucosas. The allergic tests were examined using allergic symptoms, the level of serum IgE (>100 IU/ml), the level of serum ECP (>10 μg.L) and skin test. The counts of inflammatory cells were examined using immunohistochemical staining, Hematoxylin-Eosin staining and toluidine blue staining in 40 nasal polyps, 10 allergic inferior turbinate mucosas and 10 hypertrophic inferior turbinate mucosas. Results: The allergy was detected in 4 (10%) out of 40 cases of nasal polyps, and there was no difference in eosinophil counts between nasal polyps accompanied allergy and nasal polyps not accompanied allergy. The CD4 + cells were higher than CD8 + cells in hypertrophic inferior turbinate mucosas, but CD8 + cells were significantly higher than CD4 + cells in nasal polyps. Conclusion: These results suggest that inflammation is a more important factor than allergy and T cells play a role of the pathogenesis of nasal polyp. (J Clinical Otolaryngol 2000;11:78–86)