Journal of Clinical Otolaryngology Head and Neck Surgery
The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery
원저

비용 발생에서 알레르기의 역할과 T 세포의 분포

황찬승2, 이정훈1,*, 김경환1, 백상흠1, 양훈식1, 김춘길1
Chan-Seung Hwang2, Jung-Hoon Rhee1,*, Kyung-Hwan Kim1, Sang-Heum Paik1, Hoon-Sik Yang1, Chun-Gil Kim1
1중앙대학교 의과대학 이비인후과학교실
2우리 이비인후과의원
1Department of Otolaryngology, Chungang University College of Medicine, Seoul, Korea
2Woori Otolaryngology Clinic, Kuyngido, Korea
*교신저자: 이정훈, 140-013 서울 용산구 한강로 3가 65 중앙대학교 의과대학 이비인후과학교실 전화: (02) 748-9575· 전송: (02) 792-6642 E-mail; cauent@netsgo.com

© Copyright 2000 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Dec 10, 1999; Accepted: May 24, 2000

Published Online: May 31, 2020

ABSTRACT

Background and Objective: The exact pathogenesis of nasal polyp is unknown, but inflammation is thought to be an important factor in the developement of nasal polyposis. Histologically, the stroma of nasal polyps consists of variable inflammatory cellular infiltrates. Eosinophil and lymphocyte are an important inflammatory cells. The purpose of this study is to understand the role of allergy and distribution of T cell in pathogenesis of nasal polyps. Materials and Method: We performed the analysis of allergic test and inflammatory cells in the nasal polyps, allergic inferior turbinate mucosas and hypertrophic inferior turbinate mucosas. The allergic tests were examined using allergic symptoms, the level of serum IgE (>100 IU/ml), the level of serum ECP (>10 μg.L) and skin test. The counts of inflammatory cells were examined using immunohistochemical staining, Hematoxylin-Eosin staining and toluidine blue staining in 40 nasal polyps, 10 allergic inferior turbinate mucosas and 10 hypertrophic inferior turbinate mucosas. Results: The allergy was detected in 4 (10%) out of 40 cases of nasal polyps, and there was no difference in eosinophil counts between nasal polyps accompanied allergy and nasal polyps not accompanied allergy. The CD4 + cells were higher than CD8 + cells in hypertrophic inferior turbinate mucosas, but CD8 + cells were significantly higher than CD4 + cells in nasal polyps. Conclusion: These results suggest that inflammation is a more important factor than allergy and T cells play a role of the pathogenesis of nasal polyp. (J Clinical Otolaryngol 2000;11:78–86)

Keywords: 비용; 호산구; T림프구; 면역 조직화학염색
Keywords: Nasal polyp; Eosinophil; T cell; Immunohistochemical staining