비용에서 CC Chemokines mRNA의 발현

Background: Nasal polyposis can be defined as a chronic inflammatory disease of the paranasal sinus mucosa. The exact pathogenesis of nasal polyp is unknown, but inflammation is thought to be an important factor in the developement of nasal polyposis. Histologically, the stroma of nasal polyps consists of variable inflammatory cellular infiltrates including eosinophils. Eosinophil is an important inflammatory cell. CC chemokines (RANTES, eotaxin, MCP-3, and MCP-4) are powerful chemotactic cytokines for eosinophils. Objective: To understand the events involved in eosinophil migration into inflammatory sites, we performed the analysis of CC chemokines mRNA in the nasal polyps, allergic inferior turbinate mucosas and normal inferior turbinate mucosas. Materials and Methods: Expression levels of CC chemokines mRNA were examined using RT- PCR in 20 nasal polyps, 7 allergic inferior turbinate mucosas and 6 normal inferior turbinate mucosas. Results: The expression levels of CC chemokines mRNA were higher in nasal polyps than allergic inferior turbinate mucosas and normal inferior turbinate mucosas. The expression levels of RANTES and MCP-3 mRNA were higher than eotaxin and MCP-4 mRNA (p<0.01). The infiltrating eosinophils were correlated the expression levels of RANTES, eotaxin, MCP-3, and MCP-4 mRNA (p <0.001). Conclusions: These results suggest that inflammation is an important factor in the pathogenesis of nasal polyposis and CC chemokines (RANTES, eotaxin, MCP-3, and MCP-4) play a role in eosinophils migration into inflammatory sites. With the development of immunological reagents to detect the CC chemokines, it will be important to compare proteins and mRNA expressions in these tissue. (J Clinical Otolaryngol 1999;10:250–258)