Journal of Clinical Otolaryngology Head and Neck Surgery
The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery
원저

비용에서 CC Chemokines mRNA의 발현

황찬승1,*, 이성욱1, 홍영호2, 김훈1, 김춘길1, 정학현2
Chan Seung Hwang1,*, Seong Wook Lee1, Young Ho Hong2, Hoon Kim1, Chun Gil Kim1, Hak Hyun Jung2
1중앙대학교 의과대학 이비인후과학교실
2고려대학교 의과대학 이비인후과학교실
1Department of Otolaryngology, College of Medicine, Chung-Ang University, Seoul, Korea
2Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Korea University, Seoul, Korea
*교신저자: 황찬승, 140-717 서울 용산구 한강로 3가 65 중앙대학교 의과대학 이비인후과학교실 전화: (02) 748-9575· 전송: (02) 792-6642 E-mail: cauent@netsgo.com

© Copyright 1999 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Oct 10, 1999; Accepted: Oct 25, 1999

Published Online: May 31, 2020

ABSTRACT

Background: Nasal polyposis can be defined as a chronic inflammatory disease of the paranasal sinus mucosa. The exact pathogenesis of nasal polyp is unknown, but inflammation is thought to be an important factor in the developement of nasal polyposis. Histologically, the stroma of nasal polyps consists of variable inflammatory cellular infiltrates including eosinophils. Eosinophil is an important inflammatory cell. CC chemokines (RANTES, eotaxin, MCP-3, and MCP-4) are powerful chemotactic cytokines for eosinophils. Objective: To understand the events involved in eosinophil migration into inflammatory sites, we performed the analysis of CC chemokines mRNA in the nasal polyps, allergic inferior turbinate mucosas and normal inferior turbinate mucosas. Materials and Methods: Expression levels of CC chemokines mRNA were examined using RT- PCR in 20 nasal polyps, 7 allergic inferior turbinate mucosas and 6 normal inferior turbinate mucosas. Results: The expression levels of CC chemokines mRNA were higher in nasal polyps than allergic inferior turbinate mucosas and normal inferior turbinate mucosas. The expression levels of RANTES and MCP-3 mRNA were higher than eotaxin and MCP-4 mRNA (p<0.01). The infiltrating eosinophils were correlated the expression levels of RANTES, eotaxin, MCP-3, and MCP-4 mRNA (p <0.001). Conclusions: These results suggest that inflammation is an important factor in the pathogenesis of nasal polyposis and CC chemokines (RANTES, eotaxin, MCP-3, and MCP-4) play a role in eosinophils migration into inflammatory sites. With the development of immunological reagents to detect the CC chemokines, it will be important to compare proteins and mRNA expressions in these tissue. (J Clinical Otolaryngol 1999;10:250–258)

Keywords: 비용; RANTES; Eotaxin; MCP-3; MCP-4
Keywords: Nasal polyp; RANTES; Eotaxin; MCP-3; MCP-4