원저

실험적으로 유도된 이독성 난청에서의 Ginkgo Extract 의 효과

이상흔1, 조영채1, 도현우1, 강현욱1, 조태환1
Sang Heun Lee1, Young Chae Cho1, Hyun Woo Do1, Hyun Wook Kang1, Tae Hwan Cho1
Author Information & Copyright
1경북대학교 의과대학 이비인후과학교실
1Department of Otolaryngology, School of Medicine, Kyung Pook National University

© Copyright 1998 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: May 31, 2020

ABSTRACT

This study was designed to investigate the effect of Ginkgo biloba extract on the kanamycin induced ototoxicity in inner ears of 22 guinea pigs. The animals were divide into 4 groups.

In ototoxic group, kanamycin was injected 400mg/kg per day for 7 to 10 days. In preventive treated group, kanamycin with same dose and Ginkgo biloba extract(50mg/kg) were simultaneously injected daily for same duration. In post treated toup, Ginkgo extract was treated for 15 days in kanamycin injected group. The Preyer's reflex and DP-OAE (distortion product otoacoustic emissions) were used for the monitoring of hearing changes. In the ototoxic group, the amplitude of DP-OAE was marked decreased or disappeared in all test frequencies or 4KHz only. The Preyer's reflex was disappeared in all ototoxic group. In the preventive treated group with Ginkgo extract, normal DP-OAE or slightly decreased DP-OAE in 4KHz was noticed. This finding was seemed to be similar to the post-treated group. From the above results, Ginkgo extract is suggested to have beneficial effects for the management of ototoxicity and sensorineural hearing loss.

Keywords: Ototoxicity; Ginkgo extract