원저

비폴립점막과 인접 중비갑개점막 및 부비동점막의 비만세포에 대한 관찰

이현구1, 박춘근1
Hyeon Koo Lee1, Chun Keun Park1
Author Information & Copyright
1인제대학교 의과대학 이비인후과학교실
1Depanment of Otolaryngology, College of Medicine, Inje University

© Copyright 1997 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: May 31, 2020

ABSTRACT

The distribution of mast cells in the mucosa, obtained surgically from polyp and adjacent middle turbinate, maxillary antrum, and ethmoid cells of patients with nasal polyp, was observed liistopathologically by means of staining with toluidine blue after fixation with 10% formalin or ÏVlota' s solution. The purpose of this study was to elucidate the distribution of mast cells in the mucosa of various histopathological types(edematous, glandular, and fibrous) of nasal polyp, and to compare the distribution of mast cells between nasal polyps and adjacent tissues, and to find out any clue about the reason why the mucosa of ethmoid cells was most frequent site of nasal polyp.

The results were as follows:

  1. Histopathologic types of nasal polyp were edematous(66.7%), gandular(16.7%), and fibrous(16.7%).

  2. Mast cells were distributed significantly more in both edematous and glandular types than in fibrous one(P < 0.05).

  3. Mast cells were distributed more in the mucosa of nasal polyp than in that of middle turbinate, maxillary and ethmoid sinuses(P < 0.05).

  4. Formalin—sensitive mast cells account for more than 30% of all mast cells in various tissues. With the results of this study, it is concluded that mast cells are essentially involved for the formation of nasal polyp. But, as it does not elucidate why nasal polyps occur predominantly in the mucosa around middle or superior meatus, it also can be concluded that there might be another influencing factors as well as mast cells for the formation of nasal polyp, and they should be clarified in the future.

Keywords: Formalin-sensitive mast cells; Mast cells; Nasal polyp