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비폴립점막과 인접 중비갑개점막 및 부비동점막의 비만세포에 대한 관찰
Published Online: May 31, 2020
ABSTRACT
The distribution of mast cells in the mucosa, obtained surgically from polyp and adjacent middle turbinate, maxillary antrum, and ethmoid cells of patients with nasal polyp, was observed liistopathologically by means of staining with toluidine blue after fixation with 10% formalin or ÏVlota' s solution. The purpose of this study was to elucidate the distribution of mast cells in the mucosa of various histopathological types(edematous, glandular, and fibrous) of nasal polyp, and to compare the distribution of mast cells between nasal polyps and adjacent tissues, and to find out any clue about the reason why the mucosa of ethmoid cells was most frequent site of nasal polyp.
The results were as follows:
Histopathologic types of nasal polyp were edematous(66.7%), gandular(16.7%), and fibrous(16.7%).
Mast cells were distributed significantly more in both edematous and glandular types than in fibrous one(P < 0.05).
Mast cells were distributed more in the mucosa of nasal polyp than in that of middle turbinate, maxillary and ethmoid sinuses(P < 0.05).
Formalin—sensitive mast cells account for more than 30% of all mast cells in various tissues. With the results of this study, it is concluded that mast cells are essentially involved for the formation of nasal polyp. But, as it does not elucidate why nasal polyps occur predominantly in the mucosa around middle or superior meatus, it also can be concluded that there might be another influencing factors as well as mast cells for the formation of nasal polyp, and they should be clarified in the future.