토끼 기관에 이식한 혈행성 연골막-구강점막 복합피판의 형태학적 연구: II. 전자현미경적 연구

Successful regeneration of a cartilage framework using perichondrium has been reported by several authors but there are some arguments surrounding mucosal regeneration. And ciliary regeneration has been considered as one of the most important factor in reestablishment of respiratory physiology.

This study was designed to investigate the differences, especially in ciliary regeneration, between nonvascularized and vascularized flaps. A morphologic study was carried out to determine the process and outcome of ciliary regeneration in the grafted mucosa at regular intervals under scanning electronmicroscopy. A nonvascularized perichondrial-mucosal composite flap with the same dimension was transferred in the control group.

On scanning electronmicrosopic examination, ciliary regeneration was earlier and more complete than in the experimental group. In the control group, immature cilia were partially present even after 6 weeks but in the experimental group, thin, irregularly protruded cilia were regenerated at 4 weeks.

Ciliary regeneration in the experimental group was superior to the control group in terms of degree and quality. In conclusion, maintenance of vascularization is essential to successful regeneration of grafted mucosa and cilia with good quality.