Published Online: May 31, 2020
The malignant mixed tumors of salivary gland are difined as carcinoma arising in a benign mixed tumor, and account for 6% of all mailignant salivary gland tumors. Clinical manifestation of malignant transformation in a benign mixed tumor include abrupt growth of pressxisting mass, pain, facial paralysis, and fixation to surrounding tissue.
The goals of treatment are complete surgical removeal, prevention of local recurrence, and prevention of distant metastasis.
Recentely, the authors experienced two cases of carcinoma ex mixed tumors arising in a benign mixed tumor. The first case which had associated facial nerve paralysis(House- Brackmann grade III) originated from parotid gland and the other originated from submandibular gland. Radical parotidectomy with neck dissection was peformed for the former, and radical submandibular gland resection with prophylactic neck dissection was done for the latter. All the patients have been well on, over one year follow up.