돌발성난청에서의 바이러스감염에 관한 연구
Published Online: May 31, 2020
Some studies for etiology of sudden deafness reveal ‘unknown origin’ but it is possible for apparent or inapparent viral infections to cause sudden hearing loss. There are many presumed causes of sudden deafness: congenital, inflammatory, vascular, neoplasm, metabolic, trauma, functional and membrane rupture. Documentations showing the cause-and-effect relation to sudden sensorineural hearing loss clarified that first, flu-like symptom commonly observed as preceedings and seasonal variation of incidence in sudden deafness second, serologic data for several causative viruses third, histopathologic changes found in experimental viral labyrinthitis.
We performed retrospective study about clinical data in 20 sudden deafness patients and measured viral antibody titer based on enzyme-linked immunosorbant assay and hemaglutinin inhibition method about Measle, Mumps, Influenza A · B, Rubella, Herpes simplex, and Varicella zoster viruses. We also compared the results of audiologic and serologic studies between presumed virus infected patients and non-infected patients.
The results were as followings:
Among 20 subjects, 9(45%) subjects were serollogically proved viral infection: 2 (10%) subjects presumed recent infection due to positive IgM antibody and 7(35%) subjects presumed infection due to increase in IgG antibody titers.
There were no significant difference in hearing gain after termination of treatment between viral infected group(23.6±15.9 dB) and non-viral infected group(18.0±22.2 dB).
viral infection is strongly suspected as a causative factor of sudden deafness.