Viral study in sudden deafness

Chon, Kyong-Myong; Goh, Eui-Kyung; Roh, Hwan-Jung; Lee, Ji-Won; Kim, Seu-Gyu; Moon, Young-II; Han, Jin-Young

doi:10.35420/jcohns.1995.6.2.192

J Clin Otolaryngol Head Neck Surg 1995; 6(2):192-202

pISSN: 1225-0244, eISSN: 2713-833X

DOI: https://doi.org/10.35420/jcohns.1995.6.2.192

원저

돌발성난청에서의 바이러스감염에 관한 연구

전경명¹, 고의경¹, 노환중¹, 이지원¹, 김서규¹, 문영일¹, 한진영²

Viral study in sudden deafness

Kyong-Myong Chon¹, Eui-Kyung Goh¹, Hwan-Jung Roh¹, Ji-Won Lee¹, Seu-Gyu Kim¹, Young-II Moon¹, Jin-Young Han²

Author Information & Copyright ▼

¹부산대학교 의과대학 이비인후과학교실

²동아대학교 의과대학 임상병리과학교실

¹Department of Otolaryngology, College of Medicine, Pusan National University

²Department of Clinical Pathology, College of Medicine, Dong-A University

© Copyright 1995 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: May 31, 2020

ABSTRACT

Some studies for etiology of sudden deafness reveal ‘unknown origin’ but it is possible for apparent or inapparent viral infections to cause sudden hearing loss. There are many presumed causes of sudden deafness: congenital, inflammatory, vascular, neoplasm, metabolic, trauma, functional and membrane rupture. Documentations showing the cause-and-effect relation to sudden sensorineural hearing loss clarified that first, flu-like symptom commonly observed as preceedings and seasonal variation of incidence in sudden deafness second, serologic data for several causative viruses third, histopathologic changes found in experimental viral labyrinthitis.

We performed retrospective study about clinical data in 20 sudden deafness patients and measured viral antibody titer based on enzyme-linked immunosorbant assay and hemaglutinin inhibition method about Measle, Mumps, Influenza A · B, Rubella, Herpes simplex, and Varicella zoster viruses. We also compared the results of audiologic and serologic studies between presumed virus infected patients and non-infected patients.

The results were as followings:

Among 20 subjects, 9(45%) subjects were serollogically proved viral infection: 2 (10%) subjects presumed recent infection due to positive IgM antibody and 7(35%) subjects presumed infection due to increase in IgG antibody titers.
There were no significant difference in hearing gain after termination of treatment between viral infected group(23.6±15.9 dB) and non-viral infected group(18.0±22.2 dB).
viral infection is strongly suspected as a causative factor of sudden deafness.

Keywords: Virus; Sudden deafness