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Polymorphic reticulosis의 임상적 고찰
Published Online: May 31, 2020
ABSTRACT
Since McBride has described a number of patients with rapid destruction of the nose and face in 1897, many terms were used interchangeably with each other. But polymorphic reticulosis is preferable, because it implies a potentially systemic disease with an unusual lymphoproliferative histopathology of variable atypical lymphoid composition.
Polymorphic reticulosis is a relentess, often fatal destructive process of the midface that may progress to involve practically all organ systems. Recently it is considered as a neoplastic process characterized by pleomorphic lymphoreticular cell infiltration pathologically identical to a lymphoreticular malignancy.
In this study, I reviewed and evaluated the clical and pathological findings of the PR patients.
The results were summarized as follow;
The most common age of onset was 4th decade, and male and female ratio was 2.6 to 1.
Main symptoms at diagnosis were nasal obstruction, purulent rhinorrhea, and ulceration.
The most common site of primary lesion was the nasal cavity and paranasal sinus.
There were 17 cases of polymorphic reticulosis, 8 cases of polymorphic reticulosis with features of malignant lymphoma. And progression to a more malignant histiopathologic type was found in 2 cases during follow-up.
Main management was radiotherapy with or without chemotherapy.
The survival of the group of polymorphic reticulosis with malignant lymphoma was inferior to that of the group of polymorphic reticulosis only.
In conclusion, polymorphic reticulosis is more closely linked to lymphoma where transitional forms between the two diseases have been observed. Pathology of atypical cell distribution apperars to be the most important factor in influencing prognosis.