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두경부 악성종양 조직에서의 c-fos 암유전자 및 β2-microglobulin의 발현양상과 악성종양전이간의 상관성에 관한 연구
Published Online: May 31, 2020
ABSTRACT
All of oncogene were first described as part of the genome of RNA tumor viruses and were subsequently shown to be of cellular origin. These genes termed cellular oncogene (c-onc) appear to have been the evolutionary progenators of viral oncogenes. It is strongly suggested that cellualr oncogene may possess an oncogenic potential. It is important to elucidate which and how cellualr oncogenes can be activated for specific tissue types of human tumors.
In order to verify the possibility that the patterns of expression of oncogenes and HLA might be related to the metastasis of human head and neck cancer, the expression of c-fos and β2-microglobulin in head and neck cancer (40 cases), and normal tissues (40 cases) were evaluated by immunohistochemical method with monoclonal antibodies.
The obtained results are as follows:
Numbers of stage II, III, IV were 14, 15，11 respectively among 40 patients and of them laryngeal cancer was highest in incidence (25 cases).
The nuclear staining of anti c-fos product monoclonal antibody in 32 cases (80.0%) and membrane reaction of anti β2-microglobulin monoclonal antibody in 35 cases (87.5%) were observed in normal cells.
The nuclei of cancer cells in 11 cases (78.6%) of stage II, 12 cases (80.0%) of stage III, 4 cases (36.4%) oi stage IV were positively stained with anti c-fos product monoclonal antibody.
The membrane of cancer cells in 13 cases (92.9%) of stage II, 13 cases (86.6%) of stage III, 4 cases (36.4%) of stage IV were positively stained with anti β2-microglobulin monoclonal antibody.
Comparison between the metastatic and non-metastatic group showed that the expression rate of c-fos product (40 : 80%) and β2-microglobulin (30 : 65%) was lower in metastatic group.(p<0.05)
The present results indicate that the overall incidences of expression in stage IV head and neck cancer of c-fos product and β2-microglobulin are significantly decreased as compared with normal counterparts and stage II. Such a difference is also noticed between metastatic and non-metastatic group.
Since the overall incidence of expression of these products is gradually decreased according to the stage of head and neck cancer and correlation with metastasis, it is conceivable that a tumor cell devoid of c-fos product and β2-microglobulin expression might be regarded as metastatic phenotype in human head and neck cancer.