J Clin Otolaryngol Head Neck Surg 1992; 3(2):296-307

pISSN: 1225-0244, eISSN: 2713-833X

DOI: https://doi.org/10.35420/jcohns.1992.3.2.296

Article

두경부 악성종양 조직에서의 c-fos 암유전자 및 β2-microglobulin의 발현양상과 악성종양전이간의 상관성에 관한 연구

김종애1, 곽정텍1, 김미라1, 이종덕1, 김태형1, 이강대1, 유태현1, 박병채1, 서진혜2
Expression of c-fos Oncogene Product and β2-microglobulin in Head and Neck Cancer : Correlation with Metastasis
Jong Ae Kim1, Jeoung Taek Kwak1, Mi Ra Kim1, Jong Duk Lee1, Tae Hyung Kim1, Kang Dae Lee1, Tai Hyun Yu1, Byung Chae Park1, Jin Hye Suh2
Author Information & Copyright ▼
1고신대학 의학부 이비인후과학 교실, 내과학 교실
2중앙연구실
1Department of Otolaryngology, Internal medicine, Kosin Medical College
2Cancer Research Institude, Kosin Medical College

© Copyright 1992 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: May 31, 2020

ABSTRACT

All of oncogene were first described as part of the genome of RNA tumor viruses and were subsequently shown to be of cellular origin. These genes termed cellular oncogene (c-onc) appear to have been the evolutionary progenators of viral oncogenes. It is strongly suggested that cellualr oncogene may possess an oncogenic potential. It is important to elucidate which and how cellualr oncogenes can be activated for specific tissue types of human tumors.

In order to verify the possibility that the patterns of expression of oncogenes and HLA might be related to the metastasis of human head and neck cancer, the expression of c-fos and β2-microglobulin in head and neck cancer (40 cases), and normal tissues (40 cases) were evaluated by immunohistochemical method with monoclonal antibodies.

The obtained results are as follows:

  1. Numbers of stage II, III, IV were 14, 15，11 respectively among 40 patients and of them laryngeal cancer was highest in incidence (25 cases).

  2. The nuclear staining of anti c-fos product monoclonal antibody in 32 cases (80.0%) and membrane reaction of anti β2-microglobulin monoclonal antibody in 35 cases (87.5%) were observed in normal cells.

  3. The nuclei of cancer cells in 11 cases (78.6%) of stage II, 12 cases (80.0%) of stage III, 4 cases (36.4%) oi stage IV were positively stained with anti c-fos product monoclonal antibody.

  4. The membrane of cancer cells in 13 cases (92.9%) of stage II, 13 cases (86.6%) of stage III, 4 cases (36.4%) of stage IV were positively stained with anti β2-microglobulin monoclonal antibody.

  5. Comparison between the metastatic and non-metastatic group showed that the expression rate of c-fos product (40 : 80%) and β2-microglobulin (30 : 65%) was lower in metastatic group.(p<0.05)

The present results indicate that the overall incidences of expression in stage IV head and neck cancer of c-fos product and β2-microglobulin are significantly decreased as compared with normal counterparts and stage II. Such a difference is also noticed between metastatic and non-metastatic group.

Since the overall incidence of expression of these products is gradually decreased according to the stage of head and neck cancer and correlation with metastasis, it is conceivable that a tumor cell devoid of c-fos product and β2-microglobulin expression might be regarded as metastatic phenotype in human head and neck cancer.

Keywords: Immunohistochemical method; Expression of c-fos oncogene; β2-microglobulin; Eetastatic phenotype

Journal of Clinical Otolaryngology Head and Neck Surgery
Department of Otolaryngology / Head and Neck Surgery, Pusan ​​National University Hospital, 179, Gudeok-ro, Seo-gu, Busan 49241, Korea
E-mail: jco.hns.1990@gmail.com

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