원저

위산 역류 질환 동물모델의 확립에 대한 예비결과보고

박성수1, 임윤성1, 왕수건1, 이진춘1, 박영민1, 이원용1, 정다운1, 신동훈2, 전태용3, 이병주1,*
Seong-Soo Park1, Yun-Sun Lim1, Soo-Geun Wang1, Jin-Choon Lee1, Young Min Park1, Won Yong Lee1, Da Woon Jung1, Dong Hun Shin2, Tae Yong Jeon3, Byung-Joo Lee1,*
Author Information & Copyright
1부산대학교 의학전문대학원 이비인후과학교실
2병리학교실
3외과학교실
1Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University, Busan, Korea
2Pathology, Pusan National University, Busan, Korea
3School of Medicine, Pusan National University, Busan, Korea
*교신저자: 이병주,602-739 부산광역시 서구 아미동 1가 10 부산대학교 의학전문대학원 이비인후과학교실 전화: (051) 240-7536· 전송: (051) 246-8668·E-mail: voiceleebj@gmail.com

© Copyright 2013 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Mar 22, 2013; Revised: Apr 12, 2013; Accepted: May 21, 2013

Published Online: May 31, 2020

ABSTRACT

Backgrounds: To investigate the pathophysiolosy of laryngopharyngeal reflux disease (LPRD), an experimental animal model is required. Therefore, we tried to make animal model of laryngopharyngeal reflux, modifying Omura’s method. Methods: In the first phase of study, we used Omura’s method to make animal model, ligating forestomach through purse-string suture. In the modified group A, pyrolic stenosis was made with 20F nelaton catether after 2 mm cut of it and forestomach was ligated by purse-string suture. In the modified group B, pyrolic stenosis was made with 20F nelaton catether and forestomach was ligated by purse-string suture. Results: The survival rate of Omura’s animal model was 0% (0/36), modified group A was 24% (5/21), and modified group B was 44% (8/18). Marked ulceration and mild erosion in the distal esophagus were observed in histological examination of modified group A, B, respectively. However, there was no definite inflammatory findings and squamous metaplasia in the larynx. Conclusions: The modified A and B methods were useful animal model of gastroesophageal reflux compared to original Omura’s method. However, further investigation was required to make an animal model of laryngopharyngeal reflux by these methods. (J Clinical Otolaryngol 2013;24:73–79)

Keywords: 인후두역류질환; 동물 모델; 백서
Keywords: Animal model; Laryngopharyngeal reflux disease; Rat


임상이비인후과 학술상 공지


안녕하십니까.

대한이비인후과학회 부산울산경남지부회에서는

회원분들의 학술 연구를 장려하는 의미에서 

2022년도부터 학술상을 신설해 수여하고자 합니다. 

 

임상이비인후과 학술상

1. 2022년에 본 학술지에 게재된 논문중

인용횟수 및 학술적 가치가 높은 연구주제에 대해

편집위원회에서 선정 후 수여

2. 수상자는 논문의 교신저자로 함

3. 시상 - 상장 및 상금 50만원

4. 시상일 - 추후 공지

5. 편집위원회에서 선정하므로 별도의 신청 필요 없음

 

- 관련문의 

 임상이비인후과 편집위원회  jco.hns.1990@gmail.com


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