원저

소아의 만성비부비동염에 동반되는 비용의 임상양상 및 조직학적 특성: 성인과의 비교연구

홍성룡1, 정한진1, 신재민1, 안용휘1, 한두희1, 원태빈1, 김동영1, 이재서1, 민양기1,*
Sung-Lyong Hong1, Hahn Jin Jung1, Jae-Min Shin1, Yong-Hwi An1, Doo-Hee Han1, Tae-Bin Won1, Dong-Young Kim1, Chae-Seo Rhee1, Yang-Gi Min1,*
Author Information & Copyright
1서울대학교 의과대학 이비인후과학교실
1Department of Otorhinolaryngology, Seoul National University Hospital, Seoul, Korea
*교신저자: 민양기, 110-744 서울 종로구 연건동 28 서울대학교 의과대학 이비인후과학교실 전화:(02) 2072-2447·전송:(02) 745-2387·E-mail: ygmin312@naver.com

© Copyright 2011 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Aug 31, 2011; Revised: Sep 15, 2011; Accepted: Oct 17, 2011

Published Online: May 31, 2020

ABSTRACT

Background and Objectives: Nasal polyps (NPs) in children often make the treatment of chronic rhinosinus- itis (CRS) difficult. However, there have been few studies focused on pediatric NPs. The authors attempted to investigate the clinical and pathological features of NP in pediatric CRS by comparing them with those in adult CRS and to determine risk factors for their recurrence. Materials and Methods: This study included a total of 286 adults and 56 children who were diagnosed with CRS with bilateral NPs and were treated at Seoul National University Hospital between 2005 and 2008. Their demographic data and information about comorbidities (allergic rhinitis and asthma), preoperative serum total IgE levels, peripheral blood eosinophil counts and the recurrence of NPs were collected by a retrospective chart review. In addition, the polyp tissues were harvested and stained with hematoxylin-eosin for counting the total number of inflammatory cells, including eosinophils. Results: The prevalence of allergic rhinitis was higher in the pediatric group than in the adult group (46.4% versus 30.8%). However, total IgE levels and the proportion of eosinophilic polyps were lower in the pediatric group than in the adult group (99.2 versus 246.9 kU/L and 16.7% versus 30.1%, respectively). In the pediatric group, patients with asthma, peripheral blood eosinophilia or eosinophilic NPs were at higher risk of NP recurrence. Conclusions: The clinical and pathological characteristics of pediatric patients with NPs were different from those of adult patients. Pediatric patients with asthma, peripheral blood eosinophilia or eosinophilic NPs should be aggressively managed to decrease the recurrence of NPs. (J Clinical Otolaryngol 2011;22:208–214)

Keywords: 비용; 부비동염; 소아; 재발 호산구
Keywords: Nasal polyps; Sinusitis; Child; Recurrence; Eosinophils