원저

Interleukin-1β가 중이 진주종의 골파괴에 미치는 영향

손수준1, 신승헌1,*, 이영호1, 김창균1, 이태우2
Soo-Joon Sohn1, Seung-Heon Shin1,*, Young-Ho Lee1, Chang-Gyun Kim1, Tae-Woo Lee2
Author Information & Copyright
1대구가톨릭대학교 의과대학 이비인후과학교실
2수성예일이비인후과
1Department of Otolaryngology, College of Medicine, Daegu Catholic University, Daegu, Korea
2Susung Yael ENT Clinic, Daegu, Korea
*교신저자: 신승헌, 705-034 대구광역시 남구 대명4동 3056-6, 대구가톨릭대학교 의과대학 이비인후과학교실 전화:(053) 650-4525·전송:(053) 650-4533 E-mail:hsseung@cu.ac.kr

© Copyright 2008 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Aug 28, 2008; Revised: Sep 24, 2008; Accepted: Oct 21, 2008

Published Online: May 31, 2020

ABSTRACT

Background and Objectives: Cholesteatoma is characterized by temporal bone erosions resulting in fatal intracranial complications. Osteoclasts are the principal cell of bone resorption playing a major role in focal bone erosion associated with cholesteatoma. Inflammatory cytokines such as interleukins and tumor necrosis factor are implicated in osteoclastic bone resorption. This study was conducted in order to investigate the effect of interleukin-1β(IL-1β) on bone resorption in cholesteatoma. Materials and Methods: The concentration of IL-1β in cholesteatoma epithelium was measured by enzyme linked immunosorbent assay. The effects of osteoclastogenesis and osteoclastic bone resoption were measured in receptor activator for NF-κB ligand-induced mouse osteoclast cultures and by osteoclastic bone resorption assay. Results: The concentration of IL-1β in cholesteatoma epithelium was significantly elevated compared with control. Treatment with IL-1β (10 ng/mL and 100 ng/mL) significantly increased osteoclastogenesis. The resorption surface area on dentin slices were significantly increased by osteoclasts which were stimulated with IL-1β(10 ng/mL). IL-1 receptor antagonist (10 ug/mL) blocked the upregulatory effect of IL-1β on osteoclastogenesis. Conclusion: These results suggest that the increased IL-1β produced by cholesteatoma epithelium directly stimulates osteoclasts leading to focal bone erosion in cholesteatoma. (J Clinical Otolaryngol 2008;19:177-182)

Keywords: 진주종; 골흡수; 파골세포; Interleukin-1 beta
Keywords: Cholesteatoma; Bone resorption; Osteoclast; Interleukin-1beta


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