양측 측두골에 순차적으로 발생한 조직단핵구증 1예

Langerhans cell histiocytosis is a rare disorder characterized by a proliferation of abnormal and clonal Langerhans cells. It can involve bone, skin, lymph node, viscera, but skull involvement is the most common. The clinical spectrum of disease is quite varied, ranging from a solitary eosinophilic granuloma to diffuse multisystem involvement. We present a case of Langerhans cell histiocytosis in a 2-year-old female with left tibia and bilateral temporal bone involvement sequentially at an interval of 2 years. (J Clinical Otolaryngol 2007;18:100–103)