반전성 유두종에서 p53 유전자의 발현

Background and Objective: Inverted papilloma is benign lesion of paranasal sinuses, which occupies 0.5-4.0% of the neoplasm of nose. Pathologically, it is benign, but frequently invades surrounding tissue, resulting in recurrence. p53 gene is considered to be tumor suppressor gene. By some cause, if there is production of variant of p53, the change in cell cycle induced. In head and neck cancer, some repart variant form of p53 protein is related to progression of tumorogenesis. Human papillomavirus (HPV) is considered as a carcinogenesis of inverted papilloma. In the tumorogenesis of this virus, the mechanism of action is induction of impotence of p53 tumor suppressor gene of host. The purpose of this study is to understand the mechanism of pathogenesis and biologic characteristics of nasal inverted papilloma. Materials and Method: Immunohistochemical stain method of inverted papilloma, squamous cell ca in paranasal sinus, and hypertrophied nasal mucosa targeting of change of p53 protein. Results: The expression rates of p53 protein were respectively 80%, 17.2%, and 0% in squmous cell carcinomas, inverted papillomas, and inferior turbinate mucosas. The expression rate of p53 protein of inverted papillomas with dysplasia was higher (44.4%) than inverted papillomas without dysplasia (5%). Conclusion: By this result, the expression of p53 protein is considered to be related with malignant pontential, resulting in overmultiplication of inverted papillomas. These results showed that p53 play a role as a marker presenting malignancy of inverted papilloma. (J Clinical Otolaryngol 2001;12:229-233)