원저

비강에 발생한 혈관중심성 면역증식 질환의 임상적 분석

노환중1,*, 장형준1, 서철주1, 문영일1, 이일우1, 고의경1, 박헌수1
Hwan-Jung Roh1,*, Hyeong-Jun Jang1, Cheol-Ju Seo1, Young-Il Moon1, Il-Woo Lee1, Eui-Kyung Goh1, Heon-Soo Park1
Author Information & Copyright
1부산대학교 의과대학 이비인후과학교실
2동아대학교 의과대학 이비인후과학교실
1Department of Otolaryngology, College of Medicine, Pusan National University, Pusan, Korea
2Department of Otolaryngology-Head & Neck Surgery, Dong-A University, College of Medicine, Pusan, Korea
*교신저자: 노환중, 602-739 부산광역시 서구 아미동 1가 부산대학교 의과대학 이비인후과학교실 전화: (051) 240-7333, 7335·전송: (051) 246-8668 E-mail: rohhj@hyowon.cc.pusan.ac.kr

© Copyright 2001 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Sep 10, 2001; Accepted: Sep 14, 2001

Published Online: May 31, 2020

ABSTRACT

Background and Objectives: It is believed that angiocentric immunoproliferative lesions are a unique type of extralymphatic lymphoma characterized by localized progressive and destructive lesion in upper aerodigestive tract. We analysis the clinical feature, therapeutic result and prognosis of this disease and then plan further treatment strategy. Materials and Method: The clinical feature, therapeutic modalities and outcomes of 22 patients with angiocentric immunoproliferative lesions were reviewed. Results: The most common symptom is nasal obstruction and B symptom is positive in 8 cases (36%). The lesion frequently invade nasopharynx and oral cavity and regional cervical metastasis is also frequently made. The most common metastatic organ is the lung nevertheless infrequent. The histopathologic grading is either grade 2 (41%) or grade 3 (59%) and the clinical stages by Ann-Arbor classification are almost early stages. Therapeutic modalities were selected among only chemotherapy, only radiotherapy and combined chemotherapy and radiotherapy. Overall 5-year survival rate is 29.6%. No statistical difference of survival rate is found according to both stage and therapeutic modalities. Nevertheless it tends that treatment strategy with only radiotherapy is less effective than the others. Conclusion: The treatment strategy including chemotherapy is suspected to be more effective, especially in advanced or relapsed case. Further studies are needed for establishement of the treatment strategy including chemotherapy. (J Clinical Otolaryngol 2001;12:214-221)

Keywords: 혈관중심성 면역증식 질환; 혈관중심성 림프종; 비강
Keywords: Angiocentric immunoproliferative lesions; Angiocentric lymphoma; Nasal cavity