호산구와 Fibronectin과 Cytokine의 상호 작용이 비용의 성장에 미치는 영향

Background and Objectives: Nasal polyp is a common chronic disease of the nasal or paranasal mucosa, with histologically characterized by eosinophil infiltration and edema formation. This study was performed to investigate an integrated process of eosinophils, fibronectin, and cytokines (IL-5, TGFβ1) in the pathogenesis and growth of nasal polyp. Materials and Methods: Nasal polyp samples were taken from 71 patients during endoscopic nasal surgery. Sampled nasal polyps were differentiated by size, extent of rhinosinusitis, morphologic characteristics, infiltration cell types and fibronectin positivity. Cytokine protein content was measured by ELISA. Then correlation among these factors was analyzed. Results: Nasal polyps showing edematous morphology, severe CT stage were significantly large in size. Significant correlation among edematous morphology and fibronectin expression, cytokine protein content were also recognized. Fibronectin positivity was significantly higher in the eosinophil infiltration type. Conclusion: These findings suggest that integrated process of eosinophil, fibronectin, and cytokine (IL-5, TGFβ1) may play a key role in edema formation, which contributes to the growth of nasal polyps. (J Clinical Otolaryngol 2001;12:54-60)