비용에서 CC Chemokine Receptor 3 mRNA의 발현

Background and Objectives: Nasal polyp can be defined as a chronic inflammatory disease of the paranasal sinus mucosa, histologically characterized by massive edema and accumulaiton of eosinophils. Eosinophils in the inflammatory tissue release mediators capable of causing tissue damage. The recruiment of eosinophils to the site of inflammation are mediated by a number of chemokines, particularly eotaxin, RANTES, MCP-3, MCP-4. The receptor that mediates these action has been known CCR3 which are expressed highly on the surface of eosinophils. This study was designed to determine whether there is increased expression of CCR3 in nasal polyp and whether this is associated with eosinophil count in histopathology. Materials and Methods: We performed the light microscopic examination for histopathology and the analysis of CCR3 mRNA with RT-PCR in 20 nasal polyps, 7 allergic inferior turbinate mucosas and 6 hypertrophic inferior turbinate mucosas. Results: The number of eosinophil were higher in nasal polyps than in allergic inferior turbinate mucosas and hypertrophic inferior turbinate mucosas. The expression levels of CCR3 mRNA were higher in nasal polyps than in allergic inferior turbinate mucosas and hypertrophic inferior turbinate mucosas. The infiltrating eosinophils were correlated the expression levels of CCR3 mRNA (p <0.001, r =0.877). Conclusion: These results suggest that CCR3 is a host factors highly specialized for eosinophil recruitment in inflammation, and may be good targets for the development of selective drug for inflammatory disease where eosinophils contribute to pathogenesis. (J Clinical Otolaryngol 1999;10:217–223)