원저

정상성인에서 방사선동위원소 추적자를 이용하여 측정한 고장성 식염수(Hypertonic Saline)가 비강의 점액섬모청소능(Mucociliary Clearance)에 미치는 영향

박성국1,*, 김태섭1, 엄재욱1, 박춘근1
Seong Kook Park1,*, Tae Seop Kim1, Jae Wook Eom1, Choon Keun Park1
Author Information & Copyright
1인제대학교 의과대학 부산백병원 이비인후과학교실
1Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Inje University, Pusan, Korea
*교신저자: 박성국, 614-735 부산광역시 부산진구 개금동 633-165 인제대학교 의과대학 부산백병원 이비인후과학교실 전화: (051) 890-6379·전송: (051) 892-3831 E-mail: sinus4@chollian.net

© Copyright 1999 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Oct 19, 1998; Accepted: Apr 02, 1999

Published Online: May 31, 2020

ABSTRACT

Background and Objectives: Nasal irrigation has been used usually in the treatment of patients with acute and chronic sinusitis and has also been utilized in the postoperative care of functional endoscopic sinus surgery patients. Nasal irrigation aids in the clearance of secretion, infective debris and intranasal crust which may lead to adhesion. Solutions used for nasal irrigation should not allow any impairment on the mucociliary system which contributes to the defense mechanism of the respiratory tract. For many decades, rhinologists have used normal saline as an ideal solution for mucociliary system. Recently, there are some reports that nasal irrigation with hypertonic (3%) saline is more effective on sinusitis and postoperative care of sinus surgery than irrigation with normal saline. But those were based on data using saccharine, which is a soluble tracer. And there is no report using insoluble tracer which reflects transport ability of gel layer of the mucous blanket. Therefore we performed this test in order to evaluate the effect of hypertonic saline on nasal mucociliary clearance in normal adults. Materials and Method: We studied 20 normal adults who did not have nasal diseases, aged from 17 to 24 years old, using human albumin tagged with radioisotope (Tc 99m). Nasal flow test was done with Glatzel mirror and open side was chosen. Control measurement was done before spray of normal saline and hypertonic (3%) saline. Also, the effects of normal saline and hypertonic saline on mucociliary clearance were measured after spray. Results: After spray of normal saline, mucociliary clearance increased to 4.96±2.33 mm/min, whereas in the control group was 4.60±1.85 mm/min. However, there were no statistical differences between the normal saline group and the control group (p=0.5288). But mucociliary clearance of hypertonic saline group increased to 5.96±2.50 mm/min, whereas in the control group was 4.92 ±2.34 mm/min and there were significant differences between hypertonic saline group and the control group (p=0.0142). Conclusion: The results of this study suggest that hypertonic (3%) saline irrigation has the effect of improving nasal mucociliary clearance. Also the results suggest that hypertonic saline affects the gel layer. Further rheologic studies should be made in order to know the mechanism of effect of hypertonic saline on mucociliary clearance. (J Clinical Otolaryngol 1999;10:61-65)

Keywords: 점액섬모청소능; 고장성식염수; 방사성동 위원소
Keywords: Nasal mucociliary clearance; Hypertonic saline; Radioisotope


임상이비인후과 학술상 공지


안녕하십니까.

대한이비인후과학회 부산울산경남지부회에서는

회원분들의 학술 연구를 장려하는 의미에서 

2022년도부터 학술상을 신설해 수여하고자 합니다. 

 

임상이비인후과 학술상

1. 2022년에 본 학술지에 게재된 논문중

인용횟수 및 학술적 가치가 높은 연구주제에 대해

편집위원회에서 선정 후 수여

2. 수상자는 논문의 교신저자로 함

3. 시상 - 상장 및 상금 50만원

4. 시상일 - 추후 공지

5. 편집위원회에서 선정하므로 별도의 신청 필요 없음

 

- 관련문의 

 임상이비인후과 편집위원회  jco.hns.1990@gmail.com


I don't want to open this window for a day.