Journal of Clinical Otolaryngology Head and Neck Surgery

The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery

J Clin Otolaryngol Head Neck Surg 1998; 9(1):90-95

pISSN: 1225-0244, eISSN: 2713-833X

DOI: https://doi.org/10.35420/jcohns.1998.9.1.90

원저

후두편평 세 포암종에서 Proliferating Cell Nuclear Antigen의 발현양상

황찬승¹, 양훈식¹, 김춘길¹

Expression of Proliferating Cell Nuclear Antigen(PCNA) in Laryngeal Squamous Cell Carcinomas

Chan Seung Hwang¹, Hoon Sik Yang¹, Chun Gil Kim¹

¹중앙대학교의과대학 이비인후과학교실

¹Department of Otolaryngology, College of Medicene, Chung-Ang University, Kwangmyung Sung-Ae Hospital， Seoul，Korea

© Copyright 1998 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: May 31, 2020

ABSTRACT

Proliferating cell nuclear antigen(PCNA) indicates the cellular kinetic activity during the late G1 and S phase. Among the various approaches for evaluating the proliferative activity, PCNA has been recently introduced as an antigenic marker of cellular proliferation.

The purpose of this study was to analyze the relationship between PCNA expression and clinicopathological findings in laryngeal squamous cell carcinomas. Fourty-one cases of laryngeal squamous cell carcinomas were analyzed for the detection of PCNA by immunohistochemical technique. The PCNA expression rates were 34.34 ±18.02%, 55.23±12.97%, and 78.53±5.74% in well differentiatied, moderately differentiatied and poor differentiatioed squamous cell carcinomas of larynx respectively with statistical significance(p < 0.05). There was no correlation between PCNA expression and clinical findings.

In conclusion the PCNA index was related to cellular differentiation regardless of T stage, nodal involvement, recurrence and treatment results.

Keywords: PCNA; Laryngeal carcinoma