Journal of Clinical Otolaryngology Head and Neck Surgery
The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery
원저

중이 진주종조직에서 ICAM-1, VCAM-1, ELAM-1의 발현에 관한 연구

박재영1, 백무진2,*, 이민호2, 엄재욱2, 전병훈3
Jae-Young Park1, Moo-Jin Baek2,*, Min-Ho Lee2, Jae-Wook Eom2, Byung-Hoon Jun3
1서면메디칼 이비인후과
2인제대학교 의과대학 부산백병원 이비인후-두경부외과학교실
3서울백병원 이비인후-두경부외과학교실
1Seo-Myen Medical ENT Clinc, Busan, Korea
2Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Inje University, Busan Paik Hospital, Busan, Korea
3Seoul Paik Hospital, Seoul, Korea
*교신저자: 백무진, 614-735 부산광역시 부산진구 개금2동 633-165 인제대학교 의과대학 부산백병원 이비인후-두경부외과학교실 전화: (051) 890-6377, 6375·전송: (051) 892-3831 E-mail: mjbaek@ijnc.inje.ac.kr

© Copyright 2002 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Mar 27, 2002; Accepted: Apr 26, 2002

Published Online: May 31, 2020

ABSTRACT

Background and Objectives: Cholesteatoma is associated with an intense inflammatory reaction with resultant destruction of tissue and bone. To evaluate the potential role of several adhesion molecules in the pathogenesis of cholesteatoma and its bone destruction, the authors studied mRNA expression of three adhesion molecules in the cholesteatoma tissue. Materials and Methods: We investigated mRNA expression of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and endothelial derived leukocyte adhesion molecule-1 (ELAM-1) in 20 cholesteatoma tissues as well as in the normal postaural skins using reverse transcription-polymerase chain reaction (RT-PCR). To evaluate the relationship between degree of bone destruction and adhesion molecules, we collected different portions of cholesteatoma according to the destructive status of middle ear bony structure in 5 cases and examined the expression of the mentioned factors to be compared. Results: 0f 20 cholesteatoma, eighteen (90%) showed ELAM-1 and VCAM- 1 gene expression and 8 (40%) showed ELAM-1 mRNA. There were much lower gene expressions in the normal postaural skin than the cholesteatoma. Conclusion: These results suggest that ICAM-1 and VCAM-1 play a central role in the regulation of the inflammatory disorders observed in cholesteatoma including migration, adhesion and proliferation of inflammatory cells. (J Clinical Otolaryngol 2002;13:65–72)

Keywords: 진주종; 유착분자
Keywords: Cholesteatoma; Adhesion molecule