Journal of Clinical Otolaryngology Head and Neck Surgery
The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery

후두편평세포암종에서 Cyclooxygenase-2의 발현

조강한1,*, 김경환1, 백상흠1, 홍영호1, 양훈식1, 김훈1, 김춘길1
Kang Han Cho1,*, Kyoung Hwan Kim1, Sang Heum Paik1, Young Ho Hong1, Hoon Shik Yang1, Hoon Kim1, Chun Gil Kim1
1중앙대학교 의과대학 이비인후과학교실
1Department of Otolaryngology-Head and Neck Surgery, Chung-Ang University College of Medicine, Seoul, Korea
*교신저자: 조강한, 100-272 서울 중구 필동 2가 82-1 중앙대학교 의과대학 이비인후과학교실 전화: (02) 2260-2175·전송: (02) 2264-2174 E-mail:

© Copyright 2001 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Aug 10, 2001; Accepted: Aug 20, 2001

Published Online: May 31, 2020


Background and Objective: The increased levels of prostaglandins have been detected in multiple epithelial cancers including those of head and neck origin. The cyclooxygenase catalyzes the synthesis of prostaglandins from arachidonic acid. COX-2, the inducible form of cyclooxygenase, is upregulated in transformed cells and in malignant tissues. In laryngeal squamous cell carcinomas, COX-2 was overexpressed compared with normal mucosa from healthy volunteers. Materials and Method: The twenty one specimens were obtained from the patients with squamous cell carcinoma of the larynx. The immunohistochemistry was performed using the COX-2 monoclonal antibody. Results: The immunohistochemical stains revealed intense positive staining with the antibodies against COX-2 in the well differentiated areas of the laryngeal squamous cell carcinomas. In the moderate to poor differentiated areas of the laryngeal squamous cell carcinomas, the stains were weak or negative. The expressions of COX-2 were not affected by stages of laryngeal squamous cell carcinoma. Conclusions: The immunohistochemical analysis showed that the expressions of COX-2 in laryngeal squamous cell carcinoma were closely related with cell differentiation. Taken together, these results suggest that COX-2 may be a target for the prevention or treatment of head and neck squamous cell carcinomas. (J Clinical Otolaryngol 2001;12:244-248)

Keywords: Cyclooxygenase-2; 후두암; 편평상피세 포암종
Keywords: Cyclooxygenase-2; Laryngeal cancer