Journal of Clinical Otolaryngology Head and Neck Surgery
The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery
원저

단기간 Aldehyde에 Tanning 처리한 교원질 해면의 조직 반응

박문서1,*, 김영수1, 오재국1, 김용복1, 이동훈1
Moon Suh Park1,*, Young Soo Kim1, Jae Kook Oh1, Yong Bok Kim1, Dong Hoon Lee1
1한림대학교 의과대학 이비인후-두경부외과학교실
1Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Hallym University, Seoul, Korea
*교신저자: 박문서, 150-250 서울 영등포구 영등포동 94-200 한림대학교 의과대학 한강성심 병원 이비인후-두경부외과학교실 전화: (02) 2639-5481· 전송: (02) 2637-5480 E-mail: pmsO@channeli.net

© Copyright 1999 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Jul 15, 1999; Accepted: Dec 03, 1999

Published Online: May 31, 2020

ABSTRACT

Treating of the collagen material by chemical preservatives is a procedure to make a homograft material in otologic surgery. Chemical treatment eliminates the antigenicity of allo-or xenograft materials and enhances their physical strength for molding. To evaluate the toxicity of chemical treatment through histological method, bovine collagen sponges treated with 0.5% buffered glutaraldehyde or 4% formaldehyde solution. These sponges were inserted into subcutaneous pockets of the rats and removed after 2 and 5 days. They were stained with hematoxilin-eosin and analyzed by light microsocopy. Quantitative morphometry was done. Two days after implantation, the morphology showed cellular reaction around the all rinsed collagen sponge. Inflammatory cells were presented in the surface of the sponge. At five days after implantation, more pronounced cellular reactions were noticed around the rinsed sponge. Collagen sponge without rinsing showed markedely melted architecture with inflammatory cell infiltration. (J Clinical Otolaryngol 1999;10:259–263)

Keywords: 중이수술; 알데히드; 동종이식
Keywords: Ear surgery; Aldehyde; Homograft