Journal of Clinical Otolaryngology Head and Neck Surgery
The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery

자각성 이 명 환자에서 Ginkgo biloba extracts (Ginexin-F)의 제 3상 임상 효과

임현호1, 정근1, 최종욱1
Hyun-Ho Lim1, Keun Chung1, Jong-Ouck Choi1
1고려대학교 의과대학 이비인후一두경부외과학교실
1Department of Otolaryngology-Head and Neck Surgery, Korea University, College of Medicine

© Copyright 1996 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: May 31, 2020


Tinnitus is an aberrant perception of sound unrelated to an external source of stimulation. Because of inadequate understanding of the etiology, treatment of tinnitus has been disappointing. Various treatment protocols have been attempted for tinnitus including medication, tinnitus masker, psycological counseling, but no single treatment was proven to be the most effective method. Recently Extracts from ginkgo biloba leaf (GBE) has been reported to be effective in treatment of tinnitus. In this clinical study we used GBE for the treatment of tinnitus and evaluated its efficacy and safety. Fourty patients who have idiopathic, subjective tinnitus were divided into two group. Twenty patients were treated with GBE (Ginexin-F) for 3 months, while another twenty patients were treated with adenosin triphosphate disodium (ATP) for same peirod as control group. Nine of 16 patients (56 O had a symptomatic improvement after 3 months trial of Ginexin-F, while control group showed 25% improvement. During the clinical trial there was no significant adverse effect of Ginexin- F except mild gastrointestinal discomfort. With this results we suggest that GBE might be effective and safe drug for treatment of tinnitus of idiopathic origin.

Keywords: Ginkgo biloba extracts; Tinnitus