Journal of Clinical Otolaryngology Head and Neck Surgery
The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery
원저

수면무호흡증 환자에서의 인두조직의 전자현미경적 연구

송태현1, 차영진1, 이병돈1, 장혁순1, 강주원1, 진소영*
Tae Hyun Song1, Young Jin Cha1, Byung Don Lee1, Hyuck Soon Chang1, Ju Won Kang1, So Young Jin*
1순천향대학교 의과대학 이비인후과학교실
*해부병리학교실
1Department of Otolaryngology, College of Medicine, Soonchunhyang University, Seoul, Korea
*Anatomic Pathology, College of Medicine, Soonchunhyang University, Seoul, Korea

© Copyright 1994 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: May 31, 2020

ABSTRACT

The pathophysiologic changes that result in acquisition of obstructive sleep apnea syndrome (OSAS) are poorly understood. To identify the influence of increased pharyngeal compliance and collapsibility to the pharyngeal tissue in OSAS, transverse sections of the uvula were compared using electron microscope from 10 OSAS patients group and 4 normal control group.

The obtained results were as follows:

  1. Muscle and nerve fibers in controls group show normal appearance.

  2. In OSAS patients group, there were various degrees of changes in muscle and nerve fibers such as hypertrophy or atrophy and degeneration of muscle fibers and axonal degeneration and destruction of myelin sheath in nerve fibers.

These changes may have multiple potential effects on upper airway but the actual etiology of these changes and the effect on the development of apnea will require further investigation.

Keywords: Sleep apnea syndrome; UPPP; Electron microscopy