Journal of Clinical Otolaryngology Head and Neck Surgery
The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery

가토의 체위성 안구운동에 미치는 알코홀의 중추 및 말초효과

왕원기1, 하선재1, 소병수1, 장철호1, 이정헌1, 박병림1
Won Ki Wang1, Sun Jae Ha1, Byung Soo Soh1, Chul Ho Jang1, Jung Hun Lee1, Byung Rim Park1
1원광대학교 의과대학 이비인후과학교실·생리학교실
1Department of Otolaryngology·Physiology, College of Medcine, Wonkwang University

© Copyright 1994 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: May 31, 2020


The role of the central nervous system on generation of positional alcohol nystagmus was evaluated in unanesthetized rabbits with intravenous alcohol injection of 1∼2g/kg, body weight. The body position was changed by rolling, pitching, yawing, and eye movements were measured by means of a standard electronystagmography. Also the effect of intraventricular alcohol injection of 0.2g on eye movement was observed.

The results were obtained as follows:

  1. By rolling of the whole body, the direction of eye movement corresponded to the direction of horizontal rectus muscles, and fast phase of nystagmus showed the direction of side down position. Also, eye movement appeared when the body position was returned to neutral from unilateral side down position.

  2. Vertical eye movements were induced by pitching, which movements of both eyes were in the opposite direction each other.

  3. Eye movements induced by yawing were decreased significantly compared with the control group(p<0.0l).

  4. Spontaneous nystagmus and head deviation were occurred by unilaterally ventricular injection of alcohol, and those responses were similar to the effect in contralateral side of alcohol injection.

These results indicate that the direction of positional alcohol nystagmus in rabbits with monoocular vision is not related to the gravitational direction but consistents to the vestibuloocular reflex. And the central nervous system as well as the vestibular system takes part in the generation of positional alcohol nystagmus.

Keywords: Vestibuloocular reflex; Positional alcohol nystagmus