Journal of Clinical Otolaryngology Head and Neck Surgery
The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery
원저

타액선 다형성 선종에 대한 면역조직화학적 연구

유승주1, 김상윤1, 김성학1, 이봉재1, 추광철1, 성경제*
Seung Joo Yoo1, Sang Yoon Kim1, Seomg Hak Kim1, Bong Jae Lee1, Kwang Choi Chu1, Kyung Jeh Sung*
1울산대학교 의과대학 이비인후과학교실
*피부과학교실
1Department of Otolaryngology, College of Medicine, Ulsan University
*Dermatology, College of Medicine, Ulsan University

© Copyright 1993 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: May 31, 2020

ABSTRACT

Immunohistochemical study was performed on three cases of pleomorphic adenomas of the salivary gland to investigate the origin of neoplastic epithelium and especially about the presence of myoepithelial components.

We analyzed the distribution of immunohistochemical staining in the inner cuboidal tubular epithelium, outer flattened tubular epithelium, solid nest of epithelium, and epithelial cells of myxoid stroma ; using antiS-100 protein antibody with its α and β subunits’ anticarcinoembryonic antigen antibody, and cytokeratin antibodies (MA-902, MA-903).

The epithelial cells of myxoid stroma were positively stained only to the antiS-100 protein antibody. The inner cuboidal tubular epithelium was positively stained to all four types of antibodies. The outer flattened tubular epithelium and the solid nests were positively stained only to two types of antibodies, MA-903 and antiS-100 protein antibody which were known to be reactive to myoepithelial components.

Our study suggested that the myoepithelial components may be involved in the origin of salivary gland pleomorphic adenoma, however, multidirectional differentiation of the tumor should be considered together.

Keywords: Immunohistochemical Study; Pleomorphic Adenoma; S-100 Protein; Carcinoembryonic Antigen; Cytokeratin; Salivary Gland