Journal of Clinical Otolaryngology Head and Neck Surgery
The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery

비강 및 부비동 진균증의 임상적 고찰

이흥만1, 차흥억1, 이상학1, 최건1, 황순재1
Heung Man Lee1, Heung Eog Cha1, Sang Hak Lee1, Geun Choi1, Soon Jae Hwang1
1고려대학교 의과대학 이비인후과학교실
1Department of Otolaryngology, College of Medicine, Korea University

© Copyright 1992 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: May 31, 2020


The mycotic infections of the nose and paranasal sinus had been rare occurence about a decade before. However, with the advent of therapy with antibiotics, steroids, and chemotherapeutic agents, the incidence of the fungal infection seems to have increased recently. The disease is characterized by a wide range of initial symptoms and should be considered as a possible diagnosis in case of sinusitis refractory to routine therapy. For the diagnosis, the histopathologic study with special staining methods, such as Gomori’s methenamine silver(GMS) stain or Periodic Acid-Schiff(PAS) stain, should be performed.

We analysed the clinical history and the pathologic findings of 3 cases of aspergillosis and 7 cases of mucormycosis which were diagnosed as mycotic infection of the nose and paranasal sinus and treated between June 1984 and October 1991.

The results were as follows:

  1. The male to female ratio was 1 : 1 in total 10 cases of mycotic infection(2 : 1 in the aspergillosis and 1 : 1.3 in the mucormycosis) and the mean age was 43.8 years.

  2. There were no underlying disease in both aspergillosis and mucormycosis except in 1 case of aspergillosis with acute myelocytic leukemia.

  3. The intervals from the first symptom to hospital visit were as follows: 6 cases over 1 year, 3 cases within 3 months and 1 case at 4 months.

  4. Most common clinical manifestations were purulent rhinorhea, postnasal drip, nasal obstruction, headache and foul odor.

  5. Abnormal radiologic findings were clouding of the involved sinuses and bony destruction in 1 case.

  6. A saddle nose deformity occurred in a case of aspergillosis with acute myelocytic leukemia, which developed in the nasal cavity in spite of the treatment with Amphotericin B.

  7. In one case of aspergillosis and 6 cases of mucormycosis which were found incidentally following Caldwell-Luc’s operation, the follow-up results were good.

Keywords: Nose; Paranasal sinus; Fungal infectioni Aspergillosis, Mucormysocis)